Aim 1: we will characterize in mouse livers the subpopulations of hepatocytes that are injured and the neighboring NPCs and signals that drive inflammation, regeneration and re-establishment of homeostasis. We will use three different mouse models of liver injury that target specific regions of the liver lobule and show sexual dimorphism and partial hepatectomy for pan-lobular injury. We will capture the temporal progression in each model of injury and compare the inflammatory response in males vs females and young (3 month) vs old (24 month) mice.

Aim 2: We will characterize the cellular and molecular interactions underlying inflammation in patients with liver disease.